Get Me There. San Francisco to Des Moines
1,545 mi · 1 stop The cheapest round trip from San Francisco to Des Moines right now is $245 — Nov 9 → 13, 4 nights, 1 stop.
Best fare
Des Moines Nov 9 → 13 · 4 nights · 1 stop
In the typical range for this route ($232–$245).
Prices checked on Sep 22
By month
September 2026 $386
October 2026 $249
November 2026cheapest $245
December 2026 $253
January 2027 $317
February 2027 $320
March 2027 $369
Get the best San Francisco deals by email — most Fridays, free.
Price history
11 weeks tracked · weekly lows
All dates (720 priced)
Nov 9 → 13 4 nights · 1 stop
Oct 22 → 26 4 nights · 1 stop
Oct 30 → Nov 2 3 nights · 1 stop
Nov 13 → 16 3 nights · 1 stop
Dec 5 → 10 5 nights · 1 stop
Dec 12 → 17 5 nights · 1 stop
Oct 23 → 26 3 nights · 1 stop
Nov 6 → 9 3 nights · 1 stop
Nov 2 → 6 4 nights · 1 stop
Oct 19 → 23 4 nights · 1 stop
The Friday Deal Sheet
The week's best deals from San Francisco, most Fridays — free.